SCHEMBL10651306

SCHEMBL10651306

O=CCc1cncnc1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL347549 0.77 HCAR2 (0.31)
SCHEMBL887237 0.76
SCHEMBL8040576 0.76
SCHEMBL4816906 0.74 HIF1A (0.38)
SCHEMBL875581 0.73 ACACB (0.43)
SCHEMBL9556522 0.72 HCAR2 (0.31)
SCHEMBL458711 0.72
SCHEMBL1274791 0.71
SCHEMBL456193 0.71
SCHEMBL272335 0.70

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2697227-A1 FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS Newlink Genetics Corporation (US) 2014-02-19 EP claimed
WO-2012142237-A1 FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS NEWLINK GENETICKS CORPORATION (US) 2012-10-18 WO claimed
EP-0277520-A2 Parasiticide on a pyrimidine derivative basis BAYER AG (DE) 1988-08-10 EP claimed
WO-2024030651-A1 GPX4 INHIBITORS AND USE THEREOF SONATA THERAPEUTICS, INC. (US) 2024-02-08 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
CN-109608404-A A kind of preparation method of 4,6- dichloro pyrimidine -5- acetaldehyde 上海卡洛化学有限公司 2019-04-12 CN disclosed
EP-3110802-A1 ETHYNYL DERIVATIVES F. Hoffmann-La Roche AG (CH) 2017-01-04 EP disclosed
EP-3087074-A1 BENZENE SULFONAMIDES AS CCR9 INHIBITORS Norgine BV (NL) 2016-11-02 EP disclosed
EP-2935256-A1 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION Bristol-Myers Squibb Company (US) 2015-10-28 EP disclosed
WO-2015128307-A1 ETHYNYL DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2015-09-03 WO disclosed
WO-2015097122-A1 BENZENE SULFONAMIDES AS CCR9 INHIBITORS NORGINE B.V. (NL) 2015-07-02 WO disclosed
US-20150166569-A1 TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR GENENTECH, INC. (US) 2015-06-18 US disclosed
US-9034866-B2 Tricyclic compounds and methods of use therefor GENENTECH, INC. (US) 2015-05-19 US disclosed
EP-2814830-A1 TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR F.HOFFMANN-LA ROCHE AG (CH) 2014-12-24 EP disclosed
WO-2014098831-A1 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION BRISTOL-MYERS SQUIBB COMPANY (US) 2014-06-26 WO disclosed
US-20130217666-A1 TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR GENENTECH, INC. (US) 2013-08-22 US disclosed
WO-2013120980-A1 TRICYCLIC COMPOUNDS AND METHODS OF USE THEREFOR F. HOFFMANN-LA ROCHE AG (CH) 2013-08-22 WO disclosed
EP-0277520-A2 Parasiticide on a pyrimidine derivative basis BAYER AG (DE) 1988-08-10 EP disclosed