Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamic Acid SCHEMBL49767 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL27732867 | 0.98 | GRM8 (0.78) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL19717585 | 0.98 | GRM8 (0.78) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL28656083 | 0.98 | GRM8 (0.78) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL28078987 | 0.91 | GRM8 (0.75) | GRM8GRM6GRM7GRM4GRM3 | |
| Glutamic Acid SCHEMBL5704264 | 0.91 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL1330824 | 0.91 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRM3 | |
| Glutamic Acid SCHEMBL1554237 | 0.91 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL17127348 | 0.91 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRM3 | |
| D-Glutamate SCHEMBL1330484 | 0.91 | GRM8 (1.00) | GRM8GRM6GRM7GRM4GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662360-B | Turtle small peptide and preparation method and application thereof | 华中农业大学 | 2021-08-31 | — | — | CN | claimed |
| US-20190284282-A1 | STABLE PHARMACEUTICAL COMPOSITION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2019-09-19 | — | — | US | claimed |
| EP-3402470-A1 | STABLE PHARMACEUTICAL COMPOSITION | Dr. Reddy's Laboratories Limited (IN) | 2018-11-21 | — | — | EP | claimed |
| WO-2017122121-A1 | STABLE PHARMACEUTICAL COMPOSITION | DR. REDDY'S LABORATORIES LIMITED (IN) | 2017-07-20 | — | — | WO | claimed |
| CN-103282486-B | There is the microorganism of the ornithine throughput of improvement and use the method for this microorganisms producing ornithine | CJ CHEILJEDANG CORP. (KR) | 2016-02-17 | — | — | CN | claimed |
| CN-103282486-A | Microbes with an improved ability to produce ornithine and method for producing ornithine using same | CJ CHEILJEDANG CORP | 2013-09-04 | — | — | CN | claimed |
| US-20130137639-A1 | STABLE MIA/CD-RAP FORMULATION | SCIL TECHNOLOGY GMBH (DE) | 2013-05-30 | — | — | US | claimed |
| EP-2563809-A2 | STABLE AQUEOUS MIA/CD-RAP FORMULATIONS | Scil Technology GmbH (DE) | 2013-03-06 | — | — | EP | claimed |
| CN-102869679-A | Stable MIA/CD-RAP formulation | SCIL TECHNOLOGY GMBH | 2013-01-09 | — | — | CN | claimed |
| WO-2011134979-A9 | STABLE AQUEOUS MIA/CD-RAP FORMULATIONS | SCIL TECHNOLOGY GMBH (DE) | 2012-08-16 | — | — | WO | claimed |
| WO-2011134979-A2 | STABLE MIA/CD-RAP FORMULATION | SCIL TECHNOLOGY GMBH (DE) | 2011-11-03 | — | — | WO | claimed |
| WO-2010085731-A2 | PRODUCTION OF 1,4 BUTANEDIOL IN A MICROORGANISM | MICROBIA, INC. (US) | 2010-07-29 | — | — | WO | claimed |
| CN-120731949-A | Amino acid ionic liquid and application thereof | 农业农村部环境保护科研监测所 | 2025-10-03 | — | — | CN | disclosed |
| CN-117321069-A | Vaccine composition based on attenuated reovirus and use thereof | 百洛克株式会社 | 2023-12-29 | — | — | CN | disclosed |
| US-20230058072-A1 | COSMETIC COMPOSITION | CREASEARCH BV (BE) | 2023-02-23 | — | — | US | disclosed |
| EP-4096621-A1 | COSMETIC COMPOSITION | CreaSearch BV (BE) | 2022-12-07 | — | — | EP | disclosed |
| CN-1333361-A | Novel polypeptide--human L-3-phosphoserine phosphatase 10.01 and polynucleotide for encoding said polypeptide | BODE GENE DEV CO LTD SHANGHAI (CN) | 2002-01-30 | — | — | CN | disclosed |
| CN-1199402-A | Method for production of magnesium pyridoxal-5'-phosphate glutamate and intermediate products obtained thereby | STEIGERWALD ARZNEIMITTELWERK (DE) | 1998-11-18 | — | — | CN | disclosed |
| US-5441735-A | Containing Erwinia | CENTRAL GLASS CO., LTD. (JP) | 1995-08-15 | — | — | US | disclosed |
| US-4504515-A | Process for preparing low-fat meat products and in particular sausages with high protein content | HOHENESTER HERMANN (DE) | 1985-03-12 | — | — | US | disclosed |