Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 3/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10460218 | 0.92 | MEN1 (0.43) | CHRM3MEN1HPGDKMT2ANPC1 | |
| SCHEMBL7408515 | 0.88 | CHRM3 (0.36) | CHRM3HSP90AA1MEN1HPGDKMT2A | |
| SCHEMBL10655470 | 0.87 | CHRM3 (0.58) | CHRM3HSP90AA1MEN1HPGDKMT2A | |
| SCHEMBL10656780 | 0.86 | HSP90AA1 (0.50) | CHRM3HSP90AA1LMNA | |
| SCHEMBL10655954 | 0.85 | ESR2 (0.46) | CHRM3HSP90AA1USP2ALDH1A1POLB | |
| SCHEMBL10652885 | 0.82 | CHRM3 (0.45) | CHRM3HSP90AA1MEN1KMT2AALDH1A1 | |
| SCHEMBL10655106 | 0.82 | CHRM3 (0.60) | CHRM3HSP90AA1 | |
| SCHEMBL11107621 | 0.81 | KMT2A (0.39) | CHRM3HSP90AA1MEN1HPGDKMT2A | |
| SCHEMBL10658265 | 0.80 | CHRM3 (0.48) | CHRM3HSP90AA1 | |
| SCHEMBL10654860 | 0.79 | CHRM3 (0.48) | CHRM3HSP90AA1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126654-B1 | TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF | H. LUNDBECK A/S (DK) | 1988-05-04 | — | — | EP | disclosed |
| US-4608378-A | Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems | H. LUNDBECK A/S (DK) | 1986-08-26 | — | — | US | disclosed |