Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 6/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 8/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655542 | 0.93 | CHRM3 (0.46) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10655106 | 0.90 | CHRM3 (0.60) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10655470 | 0.84 | CHRM3 (0.58) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10654860 | 0.84 | CHRM3 (0.48) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10654907 | 0.83 | CHRM3 (0.47) | CHRM3HSP90AA1HTR2AHTR2C | |
| SCHEMBL10460250 | 0.83 | CHRM3 (0.54) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10658160 | 0.81 | HTR2A (0.52) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10652190 | 0.80 | CHRM3 (0.42) | CHRM3HSP90AA1 | |
| SCHEMBL10652885 | 0.80 | CHRM3 (0.45) | CHRM3CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL10653973 | 0.79 | CHRM3 (0.58) | CHRM3CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126654-B1 | TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF | H. LUNDBECK A/S (DK) | 1988-05-04 | — | — | EP | disclosed |
| US-4608378-A | Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems | H. LUNDBECK A/S (DK) | 1986-08-26 | — | — | US | disclosed |