Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.39 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407970 | 0.89 | MAPT (0.43) | HSP90AA1CHRM3LMNAPABPC1ATM | |
| SCHEMBL10653973 | 0.86 | CHRM3 (0.58) | HSP90AA1CHRM3LMNAPABPC1ATM | |
| SCHEMBL10656068 | 0.86 | HSP90AA1 (0.52) | HSP90AA1CHRM3LMNAPABPC1ATM | |
| SCHEMBL10652190 | 0.86 | CHRM3 (0.42) | HSP90AA1CHRM3LMNA | |
| SCHEMBL10655954 | 0.82 | ESR2 (0.46) | HSP90AA1CHRM3SMN1; SMN2KDM4EMAPT | |
| SCHEMBL11107621 | 0.79 | KMT2A (0.39) | HSP90AA1CHRM3LMNASMN1; SMN2 | |
| SCHEMBL10460218 | 0.78 | MEN1 (0.43) | CHRM3LMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL10655106 | 0.77 | CHRM3 (0.60) | HSP90AA1CHRM3 | |
| SCHEMBL5533664 | 0.76 | CHRM3 (0.45) | HSP90AA1CHRM3LMNAMAPT | |
| SCHEMBL2582147 | 0.75 | HSP90AA1 (0.58) | HSP90AA1LMNAATMSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126654-B1 | TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF | H. LUNDBECK A/S (DK) | 1988-05-04 | — | — | EP | disclosed |
| US-4608378-A | Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems | H. LUNDBECK A/S (DK) | 1986-08-26 | — | — | US | disclosed |
| EP-0126654-A1 | Tetrahydroisoxazolo(4,5-c)pyridine derivatives and preparation thereof | H. LUNDBECK A/S (DK) | 1984-11-28 | — | — | EP | disclosed |