Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7160631 | 0.76 | SPHK2 (0.55) | JAK2HDAC1HDAC6NPC1SPHK2 | |
| SCHEMBL13227316 | 0.75 | KMT2A (0.55) | NPC1GLAMAPK1L3MBTL1SPHK2 | |
| SCHEMBL13663989 | 0.74 | ADORA1 (0.43) | JAK2ADORA1ALDH1A1LMNAJAK1 | |
| SCHEMBL9564261 | 0.73 | KMT2A (0.57) | NPC1GLAMAPK1L3MBTL1SPHK2 | |
| SCHEMBL16351353 | 0.73 | SPHK2 (0.44) | JAK2HDAC1HDAC6NPC1GLA | |
| SCHEMBL11016976 | 0.71 | DEGS1 (0.53) | NPC1GLAMAPK1L3MBTL1SPHK2 | |
| SCHEMBL11018471 | 0.71 | DEGS1 (0.53) | NPC1GLAMAPK1L3MBTL1SPHK2 | |
| SCHEMBL3626598 | 0.71 | DEGS1 (0.53) | NPC1GLAMAPK1L3MBTL1SPHK2 | |
| SCHEMBL16351352 | 0.71 | ALDH1A1 (0.42) | HDAC1NPC1GLAMAPK1SPHK2 | |
| SCHEMBL11015102 | 0.70 | NPC1 (0.51) | NPC1GLAMAPK1L3MBTL1SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0119591-B1 | THIODEAZAPURINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 1988-06-22 | — | — | EP | disclosed |
| US-4595530-A | Thiodeazapurine derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1986-06-17 | — | — | US | disclosed |
| EP-0119591-A1 | Thiodeazapurine derivatives | Takeda Chemical Industries, Ltd. (JP) | 1984-09-26 | — | — | EP | disclosed |