Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 13/20 | 0.53 |
| ▸ | PYGM | P11217 | 13/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7408943 | 0.85 | CYP2C9 (0.73) | CYP2C9CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL7275567 | 0.83 | PYGL (0.49) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL7434419 | 0.78 | CYP2C9 (0.61) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL7429254 | 0.78 | CYP2C9 (0.64) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL7429854 | 0.78 | CYP2C9 (0.61) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL7325004 | 0.78 | CYP2C9 (0.64) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL8438483 | 0.77 | TSHR (0.60) | CYP2C9CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL10476906 | 0.77 | CYP2C9 (0.59) | PYGLPYGMCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL11451334 | 0.76 | CYP2C9 (0.60) | CYP2C9CYP1A2CYP3A4CYP2C19MEN1 | |
| SCHEMBL11461372 | 0.76 | CYP2C9 (0.60) | CYP2C9CYP1A2CYP3A4CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093945-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1988-11-23 | — | — | EP | claimed |
| US-4495192-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-22 | — | — | US | claimed |
| EP-0093945-A2 | 1,4-Dihydropyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-11-16 | — | — | EP | claimed |
| EP-0093945-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1988-11-23 | — | — | EP | disclosed |
| US-4495192-A | HYPOTENSIVE AGENTS; VASODILATORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1985-01-22 | — | — | US | disclosed |
| EP-0093945-A2 | 1,4-Dihydropyridine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-11-16 | — | — | EP | disclosed |