Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10652350 | 0.91 | KDM4E (0.56) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10655257 | 0.89 | KDM4E (0.51) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10654374 | 0.88 | LMNA (0.42) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10483370 | 0.82 | KDM4E (0.56) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10654988 | 0.82 | MEN1 (0.52) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10654418 | 0.81 | MEN1 (0.48) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10411357 | 0.80 | KDM4E (0.51) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10652305 | 0.79 | KDM4E (0.41) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10653000 | 0.78 | KDM4E (0.45) | KDM4EMAPTHTTEDNRAMEN1 | |
| SCHEMBL10653794 | 0.78 | LMNA (0.43) | KDM4EMAPTHTTEDNRAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0092380-B1 | ANTIALLERGIC 4H-FURO(3,2-B)INDOLES AND THEIR PRODUCTION | WARNER-LAMBERT COMPANY (US) | 1988-01-20 | — | — | EP | disclosed |
| US-4596814-A | Antiallergens | WARNER-LAMBERT COMPANY (US) | 1986-06-24 | — | — | US | disclosed |
| US-4503236-A | Antiallergic 4Hfuro[3,2-b]indoles | WARNER-LAMBERT COMPANY (US) | 1985-03-05 | — | — | US | disclosed |
| EP-0092380-A2 | Antiallergic 4H-furo(3,2-b)indoles and their production | WARNER-LAMBERT COMPANY (US) | 1983-10-26 | — | — | EP | disclosed |