Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6960006 | 0.84 | ALDH1A1 (0.54) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6960011 | 0.84 | ALDH1A1 (0.54) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11889464 | 0.80 | TDP1 (0.63) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11882150 | 0.80 | TDP1 (0.63) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11259398 | 0.79 | ALDH1A1 (0.48) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11259402 | 0.79 | ALDH1A1 (0.48) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL10913779 | 0.79 | ALDH1A1 (0.49) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7275660 | 0.78 | MEN1 (0.56) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9795083 | 0.78 | ALDH1A1 (0.48) | TDP1ALDH1A1MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9657714 | 0.77 | ALDH1A1 (0.47) | TDP1ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0201558-A4 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES. | BRISTOL MYERS CO (US) | 1988-04-13 | — | — | EP | claimed |
| EP-0201558-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | Bristol-Myers Squibb Company (US) | 1986-11-20 | — | — | EP | claimed |
| WO-1986002640-A1 | DIHYDROPYRIDIN-3,5-DICARBOXYLATES INCORPORATING ARYLOXYPROPANOLAMINE MOIETIES | BRISTOL-MYERS COMPANY (US) | 1986-05-09 | — | — | WO | claimed |