Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11259398 | 1.00 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL6960011 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL6960006 | 0.85 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL9795083 | 0.84 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9657714 | 0.83 | ALDH1A1 (0.47) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL11706084 | 0.81 | SMN1; SMN2 (0.52) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL11706266 | 0.81 | SMN1; SMN2 (0.52) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL10913779 | 0.80 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL10654069 | 0.79 | TDP1 (0.54) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 | |
| SCHEMBL6956520 | 0.78 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2APKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009560-B1 | 1,4-DIHYDROPYRIDAZINE-3-CARBONYL COMPOUNDS, PROCESS FOR THEIR PREPARATION, THE COMPOUNDS FOR USE IN CURING DISEASES, MEDICAMENTS CONTAINING THEM AND PROCESS FOR THE PREPARATION OF THE MEDICAMENTS | BAYER AG (DE) | 1982-09-22 | — | — | EP | claimed |