Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | DRD5 | P21918 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 2/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10658309 | 0.87 | KDM4E (0.41) | HPGDLMNADRD1DRD5KDM4E | |
| SCHEMBL10377453 | 0.82 | FEN1 (0.43) | HPGDMAPK8ALDH1A1CYP2C19 | |
| SCHEMBL10659353 | 0.80 | HPGD (0.52) | HPGDLMNADRD1DRD5KDM4E | |
| SCHEMBL10654559 | 0.78 | DRD1 (0.41) | HPGDLMNADRD1DRD5SMN1; SMN2 | |
| SCHEMBL10659321 | 0.78 | HKDC1 (0.41) | HPGDLMNAKDM4EATML3MBTL1 | |
| SCHEMBL10658516 | 0.77 | KDM4E (0.44) | HPGDLMNADRD1DRD5KDM4E | |
| SCHEMBL10659381 | 0.76 | DRD1 (0.42) | HPGDLMNADRD1DRD5KDM4E | |
| SCHEMBL10378739 | 0.76 | HPGD (0.38) | HPGDLMNAL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10661992 | 0.75 | KDM4E (0.42) | HPGDLMNADRD1DRD5KDM4E | |
| SCHEMBL10660933 | 0.74 | SMN1; SMN2 (0.41) | LMNAKDM4EL3MBTL1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |