Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.50 |
| ▸ | FBP1 | P09467 | 1/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10654452 | 1.00 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL11486259 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL700237 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL700236 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL9803853 | 0.98 | ALDH1A1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| (Z)-1,2-Diphenylethene SCHEMBL28593492 | 0.91 | TSHR (0.70) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL1687899 | 0.90 | NR1H3 (0.56) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL11329024 | 0.89 | MAOB (0.61) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL11329021 | 0.89 | MAOB (0.61) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL8699093 | 0.88 | FBP1 (0.59) | ALDH1A1MAPTLMNAL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772534-A | PHOTORESISTS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-20 | — | — | US | disclosed |