Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.57 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PTGES | O14684 | 1/20 | 0.57 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.57 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALB | P02768 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654475 | 1.00 | PTGS2 (0.57) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10651936 | 0.92 | PTGS2 (0.54) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10651945 | 0.92 | PTGS2 (0.54) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10654094 | 0.90 | PTGS2 (0.57) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10655246 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10655227 | 0.87 | PTGS2 (0.52) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL10651074 | 0.86 | PTGS2 (0.56) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL15658049 | 0.86 | PTGS2 (0.66) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL6458883 | 0.85 | PTGS2 (0.65) | PTGS2PTGS1AKR1C3AKR1C2GLO1 | |
| SCHEMBL8430489 | 0.84 | PTGS2 (0.67) | PTGS2PTGS1AKR1C3AKR1C2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132814-B1 | ESTER DERIVATIVE OF SUBSTITUTED ACETIC ACID AND PREPARING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 1988-12-21 | — | — | EP | claimed |
| EP-0132814-A1 | Ester derivative of substituted acetic acid and preparing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | claimed |
| EP-0132814-B1 | ESTER DERIVATIVE OF SUBSTITUTED ACETIC ACID AND PREPARING THE SAME | Kaken Pharmaceutical Co., Ltd. (JP) | 1988-12-21 | — | — | EP | disclosed |
| US-4603217-A | ANTIINFLAMMATORY AGENTS | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1986-07-29 | — | — | US | disclosed |
| EP-0132814-A1 | Ester derivative of substituted acetic acid and preparing the same | Kaken Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |