Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.39 |
| ▸ | MPI | P34949 | 2/20 | 0.38 |
| ▸ | PHOSPHO1 | Q8TCT1 | 2/20 | 0.38 |
| ▸ | G6PD | P11413 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PMM2 | O15305 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655637 | 0.93 | MAT2A (0.44) | MAT2AMAPK8MAPK9MPIPHOSPHO1 | |
| SCHEMBL10658499 | 0.91 | JAK2 (0.44) | MAT2AMPIPHOSPHO1G6PDJAK2 | |
| SCHEMBL10657536 | 0.86 | MAT2A (0.52) | MAT2AMAPK8MAPK9 | |
| SCHEMBL10658461 | 0.85 | KDM4E (0.41) | MPIPHOSPHO1PMM2APOBEC3GALDH1A1 | |
| SCHEMBL10655353 | 0.85 | KMT2A (0.43) | MAPK8MAPK9ALDH1A1MEN1POLB | |
| SCHEMBL10653966 | 0.83 | JAK2 (0.45) | MAT2AMAPK8MAPK9MPIPHOSPHO1 | |
| SCHEMBL10659031 | 0.83 | EDNRA (0.44) | MAT2AMAPK8ALDH1A1KDM4ELMNA | |
| SCHEMBL10654557 | 0.81 | MAT2A (0.46) | MAT2AMAPK8MAPK9MPIPHOSPHO1 | |
| SCHEMBL10657575 | 0.79 | KMT2A (0.43) | MAT2AMAPK8MAPK9ALDH1A1MEN1 | |
| SCHEMBL10661206 | 0.79 | KMT2A (0.42) | ALDH1A1MEN1POLBKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |