Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 10/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10661982 | 0.93 | KMT2A (0.45) | KMT2ALMNAMEN1L3MBTL1EDNRA | |
| SCHEMBL10657536 | 0.91 | MAT2A (0.52) | MAT2AMAPK8MAPK9PRMT5 | |
| SCHEMBL10660728 | 0.86 | KDM4E (0.41) | LMNAMAT2AKDM4EALDH1A1MAPT | |
| SCHEMBL10661206 | 0.86 | KMT2A (0.42) | KMT2ALMNAMEN1KDM4EALDH1A1 | |
| SCHEMBL10658499 | 0.86 | JAK2 (0.44) | KMT2ALMNAMEN1MAT2AKDM4E | |
| SCHEMBL10655466 | 0.85 | HPGD (0.39) | KMT2ALMNAMEN1MAT2AMAPK8 | |
| SCHEMBL10655353 | 0.85 | KMT2A (0.43) | KMT2ALMNAMEN1L3MBTL1MAPK8 | |
| SCHEMBL10656027 | 0.83 | MAPK8 (0.51) | KMT2ALMNAMEN1L3MBTL1MAT2A | |
| SCHEMBL10660831 | 0.83 | KDM4E (0.46) | KMT2ALMNAMEN1EDNRAKDM4E | |
| SCHEMBL10656748 | 0.81 | LMNA (0.43) | KMT2ALMNAMEN1L3MBTL1EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |