Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657603 | 0.94 | HRH1 (0.43) | HRH1HTR6HSD17B10PTGDR2DAO | |
| SCHEMBL10659303 | 0.89 | HTR6 (0.48) | HRH1HTR6HSD17B10 | |
| SCHEMBL10657699 | 0.88 | PLK1 (0.43) | HSD17B10 | |
| SCHEMBL10656833 | 0.83 | HRH1 (0.42) | HRH1HTR6HSD17B10 | |
| SCHEMBL10762799 | 0.82 | HTR6 (0.50) | HRH1HTR6HSD17B10 | |
| SCHEMBL10659526 | 0.81 | PLK1 (0.44) | HSD17B10 | |
| SCHEMBL10657054 | 0.81 | ENPP2 (0.43) | PTGDR2 | |
| SCHEMBL10659533 | 0.77 | MAPT (0.43) | HSD17B10 | |
| SCHEMBL10658554 | 0.76 | HRH1 (0.43) | HRH1HTR6HSD17B10PTGDR2 | |
| SCHEMBL10659511 | 0.76 | HTR6 (0.48) | HRH1HTR6HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |