Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.33 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10836000 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GABRR1CYP1A2FOLH1NAALAD2 | |
| SCHEMBL10836004 | 1.00 | ALDH1A1 (0.39) | ALDH1A1GABRR1CYP1A2FOLH1NAALAD2 | |
| SCHEMBL701982 | 0.82 | GABRR1 (0.38) | GABRR1CYP1A2FOLH1NAALAD2ENPEP | |
| SCHEMBL18168747 | 0.82 | GABRR1 (0.38) | GABRR1CYP1A2FOLH1NAALAD2ENPEP | |
| SCHEMBL9282430 | 0.82 | GABRR1 (0.38) | GABRR1CYP1A2FOLH1NAALAD2ENPEP | |
| SCHEMBL10965683 | 0.81 | FNTA (0.48) | ALDH1A1CYP1A2GRIK1GRIK2FNTA | |
| SCHEMBL11093508 | 0.81 | FNTA (0.48) | ALDH1A1CYP1A2GRIK1GRIK2FNTA | |
| SCHEMBL10965678 | 0.81 | FNTA (0.48) | ALDH1A1CYP1A2GRIK1GRIK2FNTA | |
| SCHEMBL132111 | 0.81 | GRIK1 (0.48) | ALDH1A1GABRR1CYP1A2FOLH1NAALAD2 | |
| SCHEMBL2108415 | 0.78 | SLC1A3 (0.41) | ALDH1A1CYP1A2GRIK1GRIK2FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059158-B1 | AZA PROSTACYCLINS, THEIR PREPARATION AND THERAPEUTIC APPLICATIONS | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |
| US-4567195-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING, AKTIENGESELLSCHAFT (DE) | 1986-01-28 | — | — | US | disclosed |
| EP-0094951-B1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-10-30 | — | — | EP | disclosed |
| US-4532236-A | Certain prostacyclins and their blood-pressure-lowering and thrombocyte-aggregation-inhibiting compositions and methods | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| US-4446147-A | Azaprostacyclins, their preparation and pharmaceutical use | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-05-01 | — | — | US | disclosed |
| EP-0094951-A1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF. | SCHERING AG (DE) | 1983-11-30 | — | — | EP | disclosed |
| WO-1983001951-A1 | NEW PROSTACYCLINS AND PREPARATION METHOD THEREOF | NICKOLSON, ROBERT | 1983-06-09 | — | — | WO | disclosed |
| EP-0059158-A2 | Aza prostacyclins, their preparation and therapeutic applications | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-09-01 | — | — | EP | disclosed |