Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | LDLR | P01130 | 1/20 | 0.39 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771577 | 0.75 | CHRNB4 (0.46) | CYP1A2GAAALDH1A1TDP1LMNA | |
| SCHEMBL822807 | 0.72 | HPGDS (0.77) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL10655088 | 0.72 | PDE3B (0.54) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL10655098 | 0.69 | PDE3B (0.51) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL10651088 | 0.68 | PDE3B (1.00) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL2365544 | 0.65 | HPGDS (1.00) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL27216943 | 0.64 | HPGDS (0.54) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL8453399 | 0.63 | HPGDS (0.58) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL24418677 | 0.63 | HPGDS (0.62) | PDE3BPDE3AHPGDSLDLRPCSK9 | |
| SCHEMBL2835874 | 0.63 | HPGDS (0.67) | PDE3BPDE3AHPGDSLDLRPCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125749-B1 | IMIDAZOLYL-PYRIDAZINONES | WARNER-LAMBERT COMPANY (US) | 1988-10-05 | — | — | EP | disclosed |