Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 11/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 11/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | PDE2A | O00408 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | LDLR | P01130 | 1/20 | 0.40 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2798028 | 0.75 | SMN1; SMN2 (1.00) | PDE3BPDE3ASMN1; SMN2PDE2AAXL | |
| SCHEMBL10651798 | 0.74 | PDE3B (1.00) | PDE3BPDE3ASMN1; SMN2PDE2AAXL | |
| SCHEMBL7303341 | 0.73 | PDE3B (0.72) | PDE3BPDE3ASMN1; SMN2PDE2AAXL | |
| SCHEMBL822807 | 0.73 | HPGDS (0.77) | PDE3BPDE3AHPGDSLMNAMAPT | |
| SCHEMBL10655088 | 0.70 | PDE3B (0.54) | PDE3BPDE3ASMN1; SMN2HPGDSLMNA | |
| SCHEMBL27216943 | 0.68 | HPGDS (0.54) | PDE3BPDE3AHPGDSMAPTLDLR | |
| SCHEMBL10651516 | 0.68 | CYP1A2 (0.55) | PDE3BPDE3AHPGDSPDE4BPDE4A | |
| SCHEMBL10655098 | 0.68 | PDE3B (0.51) | PDE3BPDE3AHPGDSMAPTLDLR | |
| SCHEMBL10655094 | 0.68 | PDE3B (0.51) | PDE3BPDE3ASMN1; SMN2HPGDSLMNA | |
| SCHEMBL11627503 | 0.67 | SMN1; SMN2 (0.65) | PDE3BPDE3ASMN1; SMN2PDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0125749-B1 | IMIDAZOLYL-PYRIDAZINONES | WARNER-LAMBERT COMPANY (US) | 1988-10-05 | — | — | EP | disclosed |
| US-4521416-A | 4,5-Dihydro-6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones and 6-[(substituted)-1H-imidazol-4-yl or 5-yl]-3(2H)-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1985-06-04 | — | — | US | disclosed |
| EP-0125749-A2 | Imidazolyl-pyridazinones | WARNER-LAMBERT COMPANY (US) | 1984-11-21 | — | — | EP | disclosed |