Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.72 |
| ▸ | RAB9A | P51151 | 6/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP7 | Q93009 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14646318 | 0.87 | NPC1 (0.77) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL12349885 | 0.86 | NPC1 (0.76) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL15382775 | 0.86 | NPC1 (0.70) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL22627410 | 0.84 | NPC1 (0.72) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL971875 | 0.84 | NPC1 (1.00) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL22627455 | 0.82 | KDM4E (0.69) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL22627444 | 0.81 | RAB9A (0.72) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL22627500 | 0.81 | NPC1 (0.68) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL22627434 | 0.80 | RAB9A (0.67) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL12970529 | 0.80 | NPC1 (0.67) | NPC1RAB9AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0120589-B1 | IMIDAZO-HETEROCYCLIC COMPOUNDS, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |
| US-4621084-A | CARDIOTONIC, ANTIULCER | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-11-04 | — | — | US | disclosed |
| EP-0120589-A1 | Imidazo-heterocyclic compounds, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-10-03 | — | — | EP | disclosed |