Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | CASP7 | P55210 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657373 | 0.93 | POLB (0.36) | POLBSMN1; SMN2TSHRHTTHKDC1 | |
| SCHEMBL10658078 | 0.81 | SMN1; SMN2 (0.34) | POLBSMN1; SMN2TSHRHTTHKDC1 | |
| SCHEMBL10379002 | 0.81 | HPGD (0.35) | POLBSMN1; SMN2TSHRHSD17B10ALDH1A1 | |
| SCHEMBL10657805 | 0.79 | ALDH1A1 (0.40) | POLBSMN1; SMN2TSHRHTTHKDC1 | |
| SCHEMBL10658752 | 0.79 | EPHB4 (0.45) | SMN1; SMN2TSHRHTTALDH1A1CYP1A2 | |
| SCHEMBL10659049 | 0.78 | HPGD (0.35) | SMN1; SMN2TSHRHTTKDM4EALDH1A1 | |
| SCHEMBL10659042 | 0.75 | EPHB4 (0.34) | KDM4EALDH1A1HPGD | |
| SCHEMBL10658485 | 0.75 | HPGD (0.37) | SMN1; SMN2HKDC1KDM4EALDH1A1MAPK1 | |
| SCHEMBL10654050 | 0.74 | KDM4E (0.36) | POLBSMN1; SMN2TSHRHTTHKDC1 | |
| SCHEMBL10659635 | 0.74 | CYP1A2 (0.39) | POLBTSHRKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |