Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659049 | 0.84 | HPGD (0.35) | EPHB4SMN1; SMN2TSHRLMNAHTT | |
| SCHEMBL10377181 | 0.84 | EPHB4 (0.48) | EPHB4SMN1; SMN2CYP1A2LMNAL3MBTL1 | |
| SCHEMBL10659635 | 0.81 | CYP1A2 (0.39) | EPHB4CYP1A2TSHRLMNAKMT2A | |
| SCHEMBL10657544 | 0.80 | EPHB4 (0.44) | EPHB4SMN1; SMN2CYP1A2LMNAL3MBTL1 | |
| SCHEMBL10377092 | 0.79 | EPHB4 (0.48) | EPHB4SMN1; SMN2CYP1A2L3MBTL1USP2 | |
| SCHEMBL10653938 | 0.78 | EPHB4 (0.52) | EPHB4SMN1; SMN2CYP1A2TSHRLMNA | |
| SCHEMBL10654531 | 0.76 | SMN1; SMN2 (0.46) | EPHB4SMN1; SMN2CYP1A2L3MBTL1USP2 | |
| SCHEMBL10659042 | 0.75 | EPHB4 (0.34) | EPHB4ALDH1A1 | |
| SCHEMBL10378461 | 0.73 | EPHB4 (0.51) | EPHB4SMN1; SMN2LMNAL3MBTL1USP2 | |
| SCHEMBL10657373 | 0.73 | POLB (0.36) | SMN1; SMN2CYP1A2TSHRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |