Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10737737 | 0.87 | SOS1 (0.50) | SOS1CA12CA2CA1CA4 | |
| SCHEMBL10741860 | 0.87 | CA2 (0.42) | SOS1CA12CA2CA1CA4 | |
| SCHEMBL10652647 | 0.84 | CA12 (0.47) | SOS1CA12CA2CA1CA7 | |
| SCHEMBL10654918 | 0.83 | ALDH1A1 (0.45) | SOS1CA12CA2CA1CA4 | |
| SCHEMBL11848172 | 0.81 | TDP1 (0.57) | CA12CA2CA1CA4CA6 | |
| SCHEMBL11089561 | 0.80 | GPR17 (0.43) | CA12CA2CA1CA9ALDH1A1 | |
| SCHEMBL3072712 | 0.79 | CA2 (0.50) | SOS1CA12CA2CA1CA4 | |
| SCHEMBL17355694 | 0.79 | KMT2A (0.46) | SOS1APEX1TDP1L3MBTL1LMNA | |
| SCHEMBL11849091 | 0.78 | APEX1 (0.67) | CA12CA2CA1CA4CA6 | |
| SCHEMBL11842615 | 0.78 | APEX1 (0.50) | CA12CA2CA1CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115039-B1 | SUBSTITUTED PHENYLSULFONYLOXYBENZIMIDAZOLE CARBAMATES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-10 | — | — | EP | disclosed |
| US-4639463-A | Substituted phenylsulfonyloxybenzimidazolecarbamates and anthelmintic compositions | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-01-27 | — | — | US | disclosed |
| EP-0115039-A1 | Substituted phenylsulfonyloxybenzimidazole carbamates, process for their preparation and their application as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-08-08 | — | — | EP | disclosed |