SCHEMBL10656333

SCHEMBL10656333

O=C(c1ccc(O)c(Cl)c1Cl)c1cccc2ccccc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.56
CNR2 P34972 10/20 0.49
NR4A1 P22736 1/20 0.49
NR4A2 P43354 1/20 0.49
NR4A3 Q92570 1/20 0.49
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
MAPT P10636 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
CNR1 P21554 7/20 0.46
H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 P62805 1/20 0.46
EP300 Q09472 1/20 0.46
PRMT1 Q99873 1/20 0.46
POLB P06746 1/20 0.45
GAA P10253 1/20 0.45
MMP3 P08254 1/20 0.45
HDAC8 Q9BY41 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL247300 0.83 CDC25B (0.62) CDC25BCNR2NR4A1NR4A2NR4A3
SCHEMBL10660701 0.81 GSTA1 (0.53) MAPTHTTGAACYP2C9
SCHEMBL29414437 0.80 CDC25B (0.80) CDC25BCNR2NR4A1NR4A2NR4A3
SCHEMBL244802 0.80 CDC25B (0.80) CDC25BCNR2NR4A1NR4A2NR4A3
SCHEMBL11055051 0.80 MAPK1 (0.50) KMT2AMEN1HTTL3MBTL1CYP2C9
SCHEMBL9153610 0.80 CDC25B (0.59) CDC25BCNR2NR4A1NR4A2NR4A3
SCHEMBL10657561 0.80 CES2 (0.50) KMT2AMEN1POLBGAAIGFBP3
SCHEMBL30586611 0.79 CDC25B (0.67) CDC25BCNR2NR4A1NR4A2NR4A3
SCHEMBL6826963 0.79 CDC25B (0.67) CDC25BCNR2NR4A1NR4A2NR4A3
Hydrochloric Acid SCHEMBL27713225 0.78 CDC25B (0.77) CDC25BCNR2NR4A1NR4A2NR4A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4728662-A DIURETICS, URICOSURICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1988-03-01 US disclosed
US-4673746-A DIURETICS, HYPOTENSIVES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1987-06-16 US disclosed
EP-0002666-B1 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1982-02-17 EP disclosed
EP-0002666-A1 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them HOECHST AKTIENGESELLSCHAFT (DE) 1979-07-11 EP disclosed