⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethiodal SCHEMBL1749099 | 0.92 | — | — | |
| SCHEMBL24540172 | 0.69 | — | — | |
| SCHEMBL9765841 | 0.69 | — | — | |
| Sulfuric Acid SCHEMBL3945783 | 0.69 | — | — | |
| SCHEMBL11969893 | 0.67 | CA5A (0.42) | — | |
| Sulfuric Acid SCHEMBL22835796 | 0.65 | — | — | |
| SCHEMBL9744121 | 0.64 | CA5A (0.39) | — | |
| Sulfuric Acid SCHEMBL1921997 | 0.63 | CA5A (0.86) | — | |
| Sulfuric Acid SCHEMBL8000656 | 0.63 | CA5A (0.86) | — | |
| Sulfuric Acid SCHEMBL19741763 | 0.63 | CA5A (0.86) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11739345-B2 | Methods of treating phenylketonuria | BIOMARIN PHARMACEUTICAL INC. (US) | 2023-08-29 | — | — | US | disclosed |
| CN-114729334-A | Aminoacyl tRNA synthetases and cell lines for site-specific incorporation of unnatural amino acids | 布里克生物公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-113164762-A | Method for treating phenylketonuria | 生物马林药物股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-3790627-A2 | METHODS OF TREATING PHENYLKETONURIA | BioMarin Pharmaceutical Inc. (US) | 2021-03-17 | — | — | EP | disclosed |
| CN-111902164-A | Adeno-associated virus compositions for restoration of PAH gene function and methods of use thereof | 同源药物公司 | 2020-11-06 | — | — | CN | disclosed |
| US-20200172634-A1 | Expression Constructs and Methods for Expressing Polypeptides in Eukaryotic Cells | GLENMARK PHARMACEUTICALS S.A. (CH) | 2020-06-04 | — | — | US | disclosed |
| WO-2019217513-A2 | METHODS OF TREATING PHENYLKETONURIA | BIOMARIN PHARMACEUTICAL INC. (US) | 2019-11-14 | — | — | WO | disclosed |
| US-20170253671-A1 | Expression Constructs and Methods for Expressing Polypeptides in Eukaryotic Cells | GLENMARK PHARMACEUTICALS S.A. (CH) | 2017-09-07 | — | — | US | disclosed |
| EP-3030579-A1 | EXPRESSION CONSTRUCTS AND METHODS FOR EXPRESSING POLYPEPTIDES IN EUKARYOTIC CELLS | Glenmark Pharmaceuticals S.A. (CH) | 2016-06-15 | — | — | EP | disclosed |
| US-20150056655-A1 | EXPRESSION CONSTRUCTS AND METHODS FOR EXPRESSING POLYPEPTIDES IN EUKARYOTIC CELLS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-02-26 | — | — | US | disclosed |
| US-20110014624-A1 | Methods For Identifying Cells Suitable For Large-Scale Production of Recombinant Proteins | WYETH LLC (US) | 2011-01-20 | — | — | US | disclosed |
| EP-2257634-A1 | METHOD FOR IDENTIFYING CELLS SUITABLE FOR LARGE-SCALE PRODUCTION OF RECOMBINANT PROTEINS | Wyeth LLC (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009114693-A1 | METHOD FOR IDENTIFYING CELLS SUITABLE FOR LARGE-SCALE PRODUCTION OF RECOMBINANT PROTEINS | WYETH (US) | 2009-09-17 | — | — | WO | disclosed |
| US-20090004735-A1 | Promoter and its use | GEORGE MASON UNIVERSITY | 2009-01-01 | — | — | US | disclosed |
| US-7011973-B1 | Regulatory sequences capable of conferring expression of a heterologous DNA sequence in endothelial cells in vivo and uses thereof | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2006-03-14 | — | — | US | disclosed |
| EP-1007714-B1 | REGULATORY SEQUENCES CAPABLE OF CONFERRING EXPRESSION OF A HETEROLOGOUS DNA SEQUENCE IN ENDOTHELIAL CELLS IN VIVO AND USES THEREOF | MAX PLANCK GESELLSCHAFT (DE) | 2005-12-14 | — | — | EP | disclosed |
| US-20050235367-A1 | Regulatory sequences capable of conferring expression of a heterologous DNA sequence in endothelial cells and uses thereof | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. | 2005-10-20 | — | — | US | disclosed |
| EP-1007714-A1 | REGULATORY SEQUENCES CAPABLE OF CONFERRING EXPRESSION OF A HETEROLOGOUS DNA SEQUENCE IN ENDOTHELIAL CELLS IN VIVO AND USES THEREOF | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin (DE) | 2000-06-14 | — | — | EP | disclosed |
| WO-1998055638-A9 | REGULATORY SEQUENCES CAPABLE OF CONFERRING EXPRESSION OF A HETEROLOGOUS DNA SEQUENCE IN ENDOTHELIAL CELLS IN VIVO AND USES THEREOF | MAX PLANCK GESELLSCHAFT (DE) | 1999-04-08 | — | — | WO | disclosed |
| WO-1998055638-A1 | REGULATORY SEQUENCES CAPABLE OF CONFERRING EXPRESSION OF A HETEROLOGOUS DNA SEQUENCE IN ENDOTHELIAL CELLS IN VIVO AND USES THEREOF | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 1998-12-10 | — | — | WO | disclosed |