Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4364228 | 0.88 | FUCA1 (0.50) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL1338175 | 0.86 | ACHE (0.53) | DPP4SIGMAR1ACHECCR5 | |
| SCHEMBL8224568 | 0.85 | RORC (0.56) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL5836807 | 0.84 | FUCA1 (0.60) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL19327458 | 0.84 | FUCA1 (0.60) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL7575241 | 0.84 | FUCA1 (0.60) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL16553579 | 0.83 | DPP4 (0.49) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL19098820 | 0.83 | GBA1 (0.65) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL19083303 | 0.83 | GBA1 (0.65) | DPP4GBA1FUCA1S1PR5S1PR1 | |
| SCHEMBL7813142 | 0.83 | GBA1 (0.65) | DPP4GBA1FUCA1S1PR5S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132845-B1 | NOVEL 1,8-NAPHTHYRIDINE DERIVATIVES, AND PROCESS FOR PREPARATION THEREOF | Dainippon Pharmaceutical Co., Ltd. (JP) | 1988-04-13 | — | — | EP | disclosed |
| US-4649144-A | Antibacterial 7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1987-03-10 | — | — | US | disclosed |
| EP-0132845-A2 | Novel 1,8-Naphthyridine derivatives, and process for preparation thereof | Dainippon Pharmaceutical Co., Ltd. (JP) | 1985-02-13 | — | — | EP | disclosed |