Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 6/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | STAT6 | P42226 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.38 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657187 | 0.95 | THRB (0.50) | THRBTHRAHDAC8HDAC1MEN1 | |
| SCHEMBL22317250 | 0.86 | THRB (0.56) | THRBTHRAMEN1KMT2APAK1 | |
| SCHEMBL11654830 | 0.85 | THRB (0.47) | THRBTHRAHDAC8HDAC1MEN1 | |
| SCHEMBL11653400 | 0.85 | THRB (0.47) | THRBTHRAHDAC8HDAC1MEN1 | |
| SCHEMBL11656296 | 0.83 | GSTP1 (0.52) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL11603324 | 0.83 | THRB (0.52) | THRBTHRAMEN1KMT2APAK1 | |
| SCHEMBL11710081 | 0.81 | STING1 (0.52) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8571105 | 0.81 | HTR2A (0.55) | MEN1KMT2AALDH1A1CYP1A2POLB | |
| SCHEMBL8572360 | 0.81 | HTR2A (0.54) | THRBTHRAHDAC8HDAC1MEN1 | |
| SCHEMBL11460627 | 0.79 | HMGCR (0.50) | THRBTHRAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731470-A | BRAIN INJURY PREVENTION AND TREATMENT | MERCK & CO., INC. (US) | 1988-03-15 | — | — | US | disclosed |