Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 10/20 | 0.74 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL10945469 | 0.93 | TBXAS1 (0.65) | TBXAS1CYP19A1 | |
| Fumaric Acid SCHEMBL10945447 | 0.93 | TBXAS1 (0.65) | TBXAS1CYP19A1 | |
| SCHEMBL11354168 | 0.87 | TBXAS1 (0.74) | TBXAS1CYP19A1CYP11B1CYP11B2PLA2G4A | |
| SCHEMBL10851510 | 0.87 | TBXAS1 (0.67) | TBXAS1CYP19A1 | |
| SCHEMBL10948037 | 0.86 | TBXAS1 (0.61) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL10748096 | 0.85 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL29239321 | 0.84 | TBXAS1 (0.70) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL10852178 | 0.83 | TBXAS1 (1.00) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11706257 | 0.82 | KDM4E (0.68) | TBXAS1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL11474932 | 0.82 | TBXAS1 (0.67) | TBXAS1CYP19A1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731370-A | VASODILATOR, ANTICOAGULANT | TOYAMA CHEMICAL CO., LTD. (JP) | 1988-03-15 | — | — | US | disclosed |
| US-4713387-A | Vasodilating and platelet aggregation inhibiting 1,4 dihydropyridines with an imidazolyl or pyridyl containing ester | TOYAMA CHEMICAL CO., LTD. (JP) | 1987-12-15 | — | — | US | disclosed |
| US-4632934-A | THROMBOXANE SYNTHETASE INHIBITORS | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 1986-12-30 | — | — | US | disclosed |
| US-4555516-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1985-11-26 | — | — | US | disclosed |
| US-4461905-A | THROMBOXANE SYNTHETASE INHIBITOR INTERMEDIATE | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-07-24 | — | — | US | disclosed |
| US-4448781-A | CARDIOVASCULAR DISORDERS | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |