Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10662007 | 0.93 | ALDH1A1 (0.39) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10377461 | 0.87 | MAPT (0.35) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10378428 | 0.87 | PDE4A (0.39) | CYP1A2CYP2C19MEN1KMT2AHPGD | |
| SCHEMBL10660843 | 0.86 | MAPT (0.39) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10377181 | 0.85 | EPHB4 (0.48) | MAPTCYP1A2PDE4BPDE4DPDE4A | |
| SCHEMBL9629146 | 0.85 | MAPT (0.49) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10660827 | 0.84 | PDE4B (0.39) | MAPTHPGDALDH1A1PDE4BPDE4D | |
| SCHEMBL10378431 | 0.81 | ALDH1A1 (0.37) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10659366 | 0.80 | GABRA1 (0.36) | MAPTCYP1A2CYP2C19MEN1KMT2A | |
| SCHEMBL10379002 | 0.80 | HPGD (0.35) | CYP1A2CYP2C19MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |