Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 16/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663483 | 0.88 | ADRB2 (0.53) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL9664001 | 0.87 | ADRB2 (0.63) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL10662533 | 0.87 | ADRB2 (0.63) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL10661718 | 0.87 | ADRB2 (0.63) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL4386778 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1 | |
| SCHEMBL4386774 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1 | |
| SCHEMBL10661675 | 0.83 | ADRB2 (0.66) | ADRB2ADRB1 | |
| SCHEMBL11139901 | 0.82 | ADRB2 (0.61) | ADRB2ADRB1CYP1A2CYP2D6TSHR | |
| SCHEMBL10658719 | 0.81 | ADRB2 (0.69) | ADRB2ADRB1CYP1A2CYP2D6NFKB1 | |
| SCHEMBL10661645 | 0.81 | ADRB2 (0.56) | ADRB2ADRB1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753962-A | HYPOGLYCEMIC, ANTIOBESITY AGENT | BEECHAM GROUP P.L.C. (GB) | 1988-06-28 | — | — | US | disclosed |
| US-4654371-A | ANTI-OBESITY, HYPOGLYCEMIA AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-31 | — | — | US | disclosed |
| US-4478849-A | HYPERGLYCEMIC AGENTS | BEECHAM GROUP LIMITED (GB) | 1984-10-23 | — | — | US | disclosed |
| EP-0006735-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1983-06-15 | — | — | EP | disclosed |
| EP-0006735-A1 | Secondary amines, their preparation, pharmaceutical compositions containing them and their use | BEECHAM GROUP PLC (GB) | 1980-01-09 | — | — | EP | disclosed |