Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 7/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377397 | 0.88 | PDE4A (0.39) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10379022 | 0.85 | HPGD (0.47) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10378739 | 0.81 | HPGD (0.38) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10378428 | 0.79 | PDE4A (0.39) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10661938 | 0.77 | PDE4A (0.38) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10379155 | 0.77 | HPGD (0.36) | HPGDPDE4BPDE4DALDH1A1HSD17B10 | |
| SCHEMBL10657534 | 0.76 | CYP1A2 (0.40) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10659353 | 0.76 | HPGD (0.52) | HPGDALDH1A1HSD17B10SMN1; SMN2KDM4E | |
| SCHEMBL10378751 | 0.75 | EPHB4 (0.45) | HPGDPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10378766 | 0.75 | GRM2 (0.44) | HPGDPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |