SCHEMBL10653973

SCHEMBL10653973

CCOC(=O)N1CCc2onc(OC)c2C1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM3 P20309 5/20 0.58
HSP90AA1 P07900 3/20 0.46
HTR2C P28335 1/20 0.41
LMNA P02545 2/20 0.40
PABPC1 P11940 1/20 0.40
ATM Q13315 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
AKR1B10 O60218 1/20 0.40
AKR1B1 P15121 1/20 0.40
CHRM2 P08172 1/20 0.39
CHRM4 P08173 1/20 0.39
CHRM5 P08912 1/20 0.39
CHRM1 P11229 1/20 0.39
MAPT P10636 2/20 0.39
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
NPC1 O15118 1/20 0.38
HTT P42858 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10655470 0.88 CHRM3 (0.58) CHRM3HSP90AA1HTR2CLMNASMN1; SMN2
SCHEMBL10656780 0.86 HSP90AA1 (0.50) CHRM3HSP90AA1LMNAPABPC1ATM
SCHEMBL10656068 0.84 HSP90AA1 (0.52) CHRM3HSP90AA1LMNAPABPC1ATM
SCHEMBL10653028 0.83 CHRM3 (0.60) CHRM3HSP90AA1HTR2CLMNACHRM2
SCHEMBL11115776 0.83 CHRM3 (0.60) CHRM3HSP90AA1HTR2CLMNACHRM2
SCHEMBL10655106 0.83 CHRM3 (0.60) CHRM3HSP90AA1HTR2CCHRM2CHRM4
SCHEMBL10458513 0.80 CHRM3 (0.52) CHRM3HTR2CLMNASMN1; SMN2CHRM2
SCHEMBL10658265 0.79 CHRM3 (0.48) CHRM3HSP90AA1HTR2CCHRM2CHRM4
SCHEMBL5533664 0.79 CHRM3 (0.45) CHRM3HSP90AA1HTR2CLMNAMAPT
SCHEMBL7407970 0.78 MAPT (0.43) CHRM3HSP90AA1LMNAPABPC1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0126654-B1 TETRAHYDROISOXAZOLO(4,5-C)PYRIDINE DERIVATIVES AND PREPARATION THEREOF H. LUNDBECK A/S (DK) 1988-05-04 EP disclosed
US-4608378-A Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems H. LUNDBECK A/S (DK) 1986-08-26 US disclosed