Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL12 | P48061 | 1/20 | 0.49 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657662 | 0.88 | MAPK14 (0.48) | LMNAMAPTRAB9ANPC1HPGD | |
| SCHEMBL11386183 | 0.84 | MAPT (0.46) | KCNMA1ALDH1A1LMNAPOLBMAPT | |
| SCHEMBL10567455 | 0.84 | SMN1; SMN2 (0.54) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL16527374 | 0.83 | POLB (0.66) | CXCL12ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL10661348 | 0.81 | MAPT (0.47) | KMT2AMEN1LMNAMAPTRAB9A | |
| SCHEMBL27442149 | 0.80 | SMN1; SMN2 (0.48) | ALDH1A1KMT2ALMNAMAPTRAB9A | |
| SCHEMBL10664945 | 0.80 | CXCL12 (0.42) | CXCL12KCNMA1ALDH1A1KMT2AMEN1 | |
| SCHEMBL10660567 | 0.78 | POLB (0.46) | ALDH1A1KMT2APOLBMAPTRAB9A | |
| SCHEMBL5990108 | 0.77 | NPC1 (0.53) | KCNMA1ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL10659625 | 0.76 | MAPT (0.51) | ALDH1A1KMT2ALMNAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0002666-B1 | 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |