Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10661825 | 0.88 | MAPT (0.52) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL10662162 | 0.86 | MAPK14 (0.49) | SMN1; SMN2RAB9AMAPTHPGDALDH1A1 | |
| SCHEMBL11541007 | 0.85 | ALDH1A1 (0.44) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL11386183 | 0.85 | MAPT (0.46) | NPC1RAB9AMAPTHPGDALDH1A1 | |
| SCHEMBL10660567 | 0.85 | POLB (0.46) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL10660878 | 0.84 | LMNA (0.55) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL10801573 | 0.84 | L3MBTL1 (0.46) | MAPTKMT2AALDH1A1POLBCLCN2 | |
| SCHEMBL10658396 | 0.84 | CXCL12 (0.49) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL10657662 | 0.84 | MAPK14 (0.48) | SMN1; SMN2NPC1RAB9AMAPTHPGD | |
| SCHEMBL10660587 | 0.83 | ALDH1A1 (0.53) | NPC1RAB9AMAPTKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4868188-A | 4-(Benzisothiazol-3-yl)phenoxyacetic acid 1',1'-dioxides as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0110169-A2 | 4-(Benzisothiazol-3-yl)phenoxyacetic-acid l',l'-dioxides, a process for preparing the same, intermediates thereof and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1984-06-13 | — | — | EP | disclosed |
| US-4337261-A | (1,2-Benzisoxazol)phenoxyacetic acids as diuretics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0002666-B1 | 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |
| EP-0045078-A1 | (1,2-Benzisoxazol)phenoxyacetic acids and related compounds | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1982-02-03 | — | — | EP | disclosed |
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |