Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10713056 | 0.88 | RORC (0.56) | KMT2APOLBALDH1A1LMNAKDM4E | |
| SCHEMBL11306685 | 0.86 | LMNA (0.63) | MAPTHPGDKMT2APOLBALDH1A1 | |
| SCHEMBL13798207 | 0.85 | RECQL (0.62) | SMN1; SMN2RAB9AMAPTHPGDKMT2A | |
| SCHEMBL11639769 | 0.81 | L3MBTL1 (0.44) | NPC1SMN1; SMN2RAB9AHPGDKMT2A | |
| SCHEMBL10660474 | 0.81 | KMT2A (0.61) | NPC1SMN1; SMN2RAB9AMAPTHPGD | |
| SCHEMBL10567455 | 0.81 | SMN1; SMN2 (0.54) | NPC1SMN1; SMN2RAB9AMAPTHPGD | |
| SCHEMBL6103175 | 0.80 | POLB (0.66) | SMN1; SMN2MAPTHPGDPOLBALDH1A1 | |
| SCHEMBL28098625 | 0.80 | LMNA (0.54) | RAB9AMAPTKMT2APOLBALDH1A1 | |
| SCHEMBL5990261 | 0.80 | KMT2A (0.46) | NPC1SMN1; SMN2RAB9AMAPTHPGD | |
| SCHEMBL4119074 | 0.80 | NPC1 (0.47) | NPC1SMN1; SMN2RAB9AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |