Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10654535 | 0.89 | PKM (0.42) | KAT2BMAPTCYP1A2POLBPDE4B | |
| SCHEMBL10377181 | 0.87 | EPHB4 (0.48) | EPHB4KAT2BNPC1MAPTCYP1A2 | |
| SCHEMBL10660843 | 0.85 | MAPT (0.39) | MAPTCYP1A2SMN1; SMN2PDE4BPDE4D | |
| SCHEMBL10659641 | 0.84 | PDE4B (0.39) | NPC1MAPTSMN1; SMN2PDE4BPDE4D | |
| SCHEMBL10377092 | 0.84 | EPHB4 (0.48) | EPHB4KAT2BNPC1MAPTCYP1A2 | |
| SCHEMBL10657180 | 0.84 | REN (0.36) | KAT2BPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL10654531 | 0.83 | SMN1; SMN2 (0.46) | EPHB4CYP1A2POLBSMN1; SMN2L3MBTL1 | |
| SCHEMBL10654513 | 0.81 | KAT2B (0.41) | EPHB4KAT2BNPC1MAPTCYP1A2 | |
| SCHEMBL10653938 | 0.81 | EPHB4 (0.52) | EPHB4KAT2BNPC1MAPTCYP1A2 | |
| SCHEMBL10659547 | 0.81 | ALDH1A1 (0.41) | KAT2BNPC1MAPTCYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |