Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10657848 | 0.97 | PDE3B (0.47) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10657595 | 0.82 | PTPN1 (0.46) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10657585 | 0.82 | PTPN1 (0.46) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10658721 | 0.80 | PDE3B (0.46) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10658718 | 0.80 | PDE3B (0.46) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10656359 | 0.79 | PTPN1 (0.45) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL10656364 | 0.79 | PTPN1 (0.45) | PDE3BPDE3AP2RY12MAPTALDH1A1 | |
| SCHEMBL13900803 | 0.79 | MAPT (0.57) | MAPTALDH1A1TLR4TLR2 | |
| SCHEMBL8702336 | 0.79 | MAPT (0.47) | MAPTALDH1A1BACE1TLR4TLR2 | |
| SCHEMBL10849738 | 0.77 | MAPT (0.47) | MAPTALDH1A1BACE1TLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4775674-A | CARDIOTONIC AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-10-04 | — | — | US | disclosed |