Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.72 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | HTR1D | P28221 | 2/20 | 0.59 |
| ▸ | HTR1B | P28222 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10661988 | 0.90 | KMT2A (0.70) | SMN1; SMN2HTTNCOA1NCOA3KMT2A | |
| Hydrochloric Acid SCHEMBL11286503 | 0.87 | HTT (0.59) | SMN1; SMN2HTTNCOA1NCOA3KMT2A | |
| SCHEMBL10662225 | 0.82 | KMT2A (0.64) | SMN1; SMN2HTTNCOA1NCOA3KMT2A | |
| SCHEMBL10661700 | 0.79 | KMT2A (0.76) | SMN1; SMN2HTTKMT2AKDM4ENPSR1 | |
| Hydrochloric Acid SCHEMBL10660995 | 0.79 | HTT (0.62) | SMN1; SMN2HTTNCOA1NCOA3KMT2A | |
| SCHEMBL10660245 | 0.79 | KMT2A (0.55) | SMN1; SMN2HTTNCOA1NCOA3KMT2A | |
| SCHEMBL10659604 | 0.77 | KMT2A (0.71) | SMN1; SMN2HTTKMT2AKDM4ELMNA | |
| SCHEMBL22970639 | 0.75 | SMN1; SMN2 (0.71) | SMN1; SMN2HTTKMT2AKDM4ENPSR1 | |
| SCHEMBL6604720 | 0.75 | HTR1B (1.00) | SMN1; SMN2HTTNCOA1NCOA3HTR1A | |
| SCHEMBL6604715 | 0.75 | HTR1B (1.00) | SMN1; SMN2HTTNCOA1NCOA3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766131-A | 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics | PENNWALT CORPORATION (US) | 1988-08-23 | — | — | US | disclosed |
| EP-0051190-A2 | N-(amino(or hydroxy) phenethyl)-1,2,3,4-tetrahydroisoquinolines, precursors thereof, and methods of preparation | PENNWALT CORPORATION (US) | 1982-05-12 | — | — | EP | disclosed |