Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.44 |
| ▸ | PPARG | P37231 | 9/20 | 0.44 |
| ▸ | PPARD | Q03181 | 9/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10659368 | 0.88 | PPARA (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10656221 | 0.87 | PPARA (0.40) | PPARAPPARGPPARDALDH1A1GPBAR1 | |
| SCHEMBL10663477 | 0.86 | PPARA (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10738125 | 0.80 | PPARG (0.44) | PPARAPPARGPPARDALDH1A1GPBAR1 | |
| SCHEMBL10732274 | 0.80 | GPBAR1 (0.42) | ALDH1A1HSD17B10GPBAR1PTGS1FFAR4 | |
| SCHEMBL4035353 | 0.80 | FFAR4 (0.44) | PPARAPPARGPPARDKDM4EALDH1A1 | |
| SCHEMBL10655745 | 0.80 | NPC1 (0.43) | KDM4EALDH1A1HSD17B10GPBAR1PTGS1 | |
| SCHEMBL10663076 | 0.78 | SLC22A12 (0.43) | GPBAR1PTGS1SLC22A12 | |
| SCHEMBL10661841 | 0.78 | MAPT (0.41) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10657284 | 0.78 | FFAR4 (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0002666-B1 | 1,2-BENZISOXAZOLYLOXY (OR THIO) ACETIC ACIDS AND RELATED COMPOUNDS, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |