Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 5/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.35 |
| ▸ | PPARD | Q03181 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035353 | 0.91 | FFAR4 (0.44) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10661727 | 0.90 | CASP1 (0.44) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10659227 | 0.88 | TP53 (0.39) | FFAR4GPBAR1PTGS1TP53POLB | |
| SCHEMBL10663342 | 0.87 | PKM (0.43) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10658060 | 0.87 | ALDH1A1 (0.42) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10662256 | 0.86 | ALDH1A1 (0.44) | FFAR4GPBAR1PTGS1NPC1RAB9A | |
| SCHEMBL10662964 | 0.85 | TSHR (0.43) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10661817 | 0.84 | FFAR4 (0.41) | FFAR4GPBAR1PTGS1PPARAPPARG | |
| SCHEMBL10660670 | 0.84 | TP53 (0.36) | FFAR4GPBAR1PTGS1GABRA5TP53 | |
| SCHEMBL10735991 | 0.84 | FFAR4 (0.34) | FFAR4GPBAR1PTGS1PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0002666-A1 | 1,2-Benzisoxazolyloxy (or thio) acetic acids and related compounds, process for their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-11 | — | — | EP | disclosed |