Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 12/20 | 0.40 |
| ▸ | PPARG | P37231 | 10/20 | 0.40 |
| ▸ | PPARD | Q03181 | 9/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10663477 | 0.92 | PPARA (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10663114 | 0.88 | PPARA (0.44) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10656221 | 0.83 | PPARA (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL4035353 | 0.79 | FFAR4 (0.44) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10661841 | 0.79 | MAPT (0.41) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10738125 | 0.77 | PPARG (0.44) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10663076 | 0.77 | SLC22A12 (0.43) | GPBAR1PTGS1 | |
| SCHEMBL10662256 | 0.77 | ALDH1A1 (0.44) | GPBAR1PTGS1FFAR4 | |
| SCHEMBL10657284 | 0.77 | FFAR4 (0.40) | PPARAPPARGPPARDGPBAR1PTGS1 | |
| SCHEMBL10732274 | 0.77 | GPBAR1 (0.42) | GPBAR1PTGS1CTSAGABRA5FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | claimed |
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |