Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.39 |
| ▸ | CACNG2 | Q9Y698 | 2/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10662046 | 0.91 | ADK (0.46) | GRIA1CACNG2ADKADORA2APLK4 | |
| SCHEMBL10660617 | 0.89 | STK4 (0.42) | ADKMTORSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL10659843 | 0.89 | LRRK2 (0.42) | PIK3CAGRIA1CACNG2ADKADORA2A | |
| SCHEMBL10661745 | 0.89 | PDE10A (0.44) | PIK3CAADKADORA2APLK4SMN1; SMN2 | |
| SCHEMBL10660836 | 0.89 | LMNA (0.42) | PIK3CAADKADORA2APLK4SMN1; SMN2 | |
| SCHEMBL10662500 | 0.86 | MAPT (0.47) | PIK3CAPIK3CDGRIA1CACNG2SMN1; SMN2 | |
| SCHEMBL10664690 | 0.85 | — | — | |
| SCHEMBL10658063 | 0.82 | POLB (0.38) | PIK3CAPIK3CGPIK3CDMTORPIK3R1 | |
| SCHEMBL10663857 | 0.80 | KMT2A (0.43) | PIK3CAPIK3CGPIK3CDMTORPIK3R1 | |
| SCHEMBL10660765 | 0.80 | SMN1; SMN2 (0.41) | ADKADORA2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728646-A | ANTITHROMBOTICS | DR. KARL THOMAE GMBH (DE) | 1988-03-01 | — | — | US | disclosed |
| US-4690923-A | ANTITHROMBOTICS | KARL THOMAE GMBH (DE) | 1987-09-01 | — | — | US | disclosed |
| US-4518596-A | Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido (5,4,D)-pyrimidines | DR. KARL THOMAE GMBH (DE) | 1985-05-21 | — | — | US | disclosed |
| EP-0023559-B1 | 2-(PERHYDRO-1,4-DIAZINO)-PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1984-09-19 | — | — | EP | disclosed |
| EP-0023559-A1 | 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |