Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 3/20 | 0.57 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.54 |
| ▸ | GSK3A | P49840 | 4/20 | 0.52 |
| ▸ | GSK3B | P49841 | 4/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 3/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.52 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.52 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11523664 | 0.99 | GAK (0.56) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL29822705 | 0.89 | GAK (0.56) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| Hydrochloric Acid SCHEMBL10625573 | 0.88 | GAK (0.55) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| Hydrochloric Acid SCHEMBL11738528 | 0.88 | GAK (0.55) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| Hydrochloric Acid SCHEMBL11735917 | 0.87 | GAK (0.56) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL11737693 | 0.86 | GAK (0.55) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL28845677 | 0.85 | GAK (0.54) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL28845657 | 0.85 | GAK (0.57) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL29200458 | 0.84 | GAK (0.64) | GAKMAPKAPK2GSK3AGSK3BCLK4 | |
| SCHEMBL28845680 | 0.84 | GAK (0.51) | GAKMAPKAPK2GSK3AGSK3BCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735952-A | ANTI-HYPERTENSIVE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-04-05 | — | — | US | disclosed |
| EP-0215902-A1 | PROCESS FOR 4-AMINO QUINOLINES | THE UPJOHN COMPANY (US) | 1987-04-01 | — | — | EP | disclosed |
| WO-1986005489-A1 | PROCESS FOR 4-AMINO QUINOLINES | THE UPJOHN COMPANY (US) | 1986-09-25 | — | — | WO | disclosed |
| EP-0191603-A2 | Piperidine compound | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-08-20 | — | — | EP | disclosed |
| US-4167567-A | Antihypertensive 4-aminoquinolines | THE UPJOHN COMPANY (US) | 1979-09-11 | — | — | US | disclosed |
| US-4166853-A | Antihypertensive 7-trifluoromethyl-4-aminoquinolones | THE UPJOHN COMPANY (US) | 1979-09-04 | — | — | US | disclosed |