Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665891 | 0.84 | GPBAR1 (0.36) | GPBAR1MAPTKMT2A | |
| SCHEMBL11016217 | 0.69 | GPBAR1 (0.35) | GPBAR1MAPTTP53KMT2A | |
| SCHEMBL10732274 | 0.69 | GPBAR1 (0.42) | GPBAR1MAPTTP53NPC1KMT2A | |
| SCHEMBL10662689 | 0.67 | PPARD (0.46) | CYP2C19PPARD | |
| SCHEMBL10665138 | 0.67 | MAPT (0.38) | GPBAR1MAPTTP53KMT2APPARD | |
| SCHEMBL10665132 | 0.66 | PPARA (0.40) | GPBAR1PPARD | |
| SCHEMBL10735962 | 0.64 | FFAR4 (0.39) | GPBAR1TP53NPC1PPARDL3MBTL1 | |
| SCHEMBL11212443 | 0.63 | AKT1 (0.32) | MAPTTP53 | |
| SCHEMBL8619436 | 0.62 | L3MBTL1 (0.46) | MAPTNPC1KMT2ATDP1L3MBTL1 | |
| SCHEMBL11557670 | 0.61 | CYP17A1 (0.41) | GPBAR1NPC1KMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4728662-A | DIURETICS, URICOSURICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-03-01 | — | — | US | disclosed |
| US-4673746-A | DIURETICS, HYPOTENSIVES | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1987-06-16 | — | — | US | disclosed |