Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP14 | P54578 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27289772 | 0.84 | GLA (0.38) | USP14RORCJAK2JAK3DHODH | |
| SCHEMBL9443584 | 0.77 | KDM4E (0.50) | USP14KDM4E | |
| SCHEMBL6052822 | 0.76 | PER2 (0.37) | RORCL3MBTL1GAADHODHKDM4E | |
| SCHEMBL9443480 | 0.76 | USP14 (0.48) | USP14KDM4E | |
| SCHEMBL1150397 | 0.75 | USP14 (0.43) | USP14NOTUMDHODHTDP1 | |
| SCHEMBL21666720 | 0.73 | JAK2 (0.47) | JAK2JAK3GAAKDM4E | |
| SCHEMBL27286483 | 0.72 | KDM4E (0.45) | USP14L3MBTL1KDM4E | |
| SCHEMBL27926513 | 0.72 | EDNRA (0.47) | L3MBTL1GAAGFERKDM4E | |
| SCHEMBL9443555 | 0.72 | KDM4E (0.46) | USP14JAK2JAK3GAAGFER | |
| SCHEMBL1144756 | 0.72 | KDM4E (0.47) | USP14NOTUMGAAGFERKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4730000-A | 7-SUBSTITUTED AMINO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACIDS AND ESTERS | ABBOTT LABORATORIES (US) | 1988-03-08 | — | — | US | disclosed |