Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 20/20 | 0.74 |
| ▸ | GABRB3 | P28472 | 20/20 | 0.74 |
| ▸ | GABRA3 | P34903 | 20/20 | 0.74 |
| ▸ | GABRA1 | P14867 | 19/20 | 0.74 |
| ▸ | GABRA5 | P31644 | 18/20 | 0.74 |
| ▸ | GABRA2 | P47869 | 17/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666391 | 0.89 | GABRA1 (0.77) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL7452389 | 0.83 | GABRG2 (0.53) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10662241 | 0.82 | GABRG2 (0.51) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2652789 | 0.80 | GABRA1 (1.00) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL6847244 | 0.79 | GABRA1 (0.74) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10667833 | 0.77 | GABRA1 (0.76) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10660698 | 0.76 | GABRA1 (0.74) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10667452 | 0.75 | GABRA1 (0.67) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10667033 | 0.75 | NPC1 (0.62) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL10667963 | 0.74 | NPC1 (0.61) | GABRG2GABRB3GABRA3GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4788186-A | ANXIOLYTIC AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1988-11-29 | — | — | US | claimed |
| US-4788186-A | ANXIOLYTIC AGENTS | GRUPPO LEPETIT S.P.A. (IT) | 1988-11-29 | — | — | US | disclosed |
| EP-0085840-B1 | NEW 6-SUBSTITUTED-S-TRIAZOLO(3,4-A)PHTHALAZINE DERIVATIVES | GRUPPO LEPETIT S.P.A. (IT) | 1986-10-01 | — | — | EP | disclosed |
| EP-0085840-A1 | New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives | GRUPPO LEPETIT S.P.A. (IT) | 1983-08-17 | — | — | EP | disclosed |