Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9837932 | 0.87 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2HPGDALOX15 | |
| SCHEMBL9837751 | 0.87 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL9838903 | 0.86 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL10518993 | 0.86 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2HPGDALOX15 | |
| SCHEMBL9839261 | 0.86 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL10524820 | 0.85 | HSPA5 (0.40) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL10667122 | 0.84 | KDM4E (0.40) | KMT2AKDM4EALOX15MAPK1HSPA5 | |
| SCHEMBL10666263 | 0.81 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL9837900 | 0.81 | HSPA5 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AHPGD | |
| SCHEMBL10737592 | 0.80 | HSPA5 (0.44) | NPC1RAB9ASMN1; SMN2KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735951-A | Novel 4-hydroxy-3-quinoline-carboxylates having analgesic and anti-inflammatory activity | ROUSSEL UCLAF (FR) | 1988-04-05 | — | — | US | disclosed |