Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.52 |
| ▸ | THRA | P10827 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | USP2 | O75604 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10667480 | 1.00 | THRB (0.52) | THRBTHRAPPARGGRIA2SIRT5 | |
| SCHEMBL2122000 | 0.89 | SLC7A5 (0.55) | THRBTHRAPPARGGRIA2SIRT5 | |
| SCHEMBL31083609 | 0.89 | SLC7A5 (0.55) | THRBTHRAPPARGGRIA2SIRT5 | |
| SCHEMBL2121998 | 0.89 | SLC7A5 (0.55) | THRBTHRAPPARGGRIA2SIRT5 | |
| Dibromotyrosine SCHEMBL145218 | 0.89 | THRB (0.58) | THRBTHRAPPARGGRIA2SIRT5 | |
| Dibromotyrosine SCHEMBL838919 | 0.89 | THRB (0.58) | THRBTHRAPPARGGRIA2SIRT5 | |
| Dibromotyrosine SCHEMBL145219 | 0.89 | THRB (0.58) | THRBTHRAPPARGGRIA2SIRT5 | |
| Dibromotyrosine SCHEMBL29399010 | 0.87 | THRB (0.57) | THRBTHRAPPARGGRIA2SIRT5 | |
| Hydrochloric Acid SCHEMBL16007570 | 0.87 | GRIA2 (0.53) | THRBTHRAPPARGGRIA2SIRT5 | |
| Hydrochloric Acid SCHEMBL16007571 | 0.87 | GRIA2 (0.53) | THRBTHRAPPARGGRIA2SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4745124-A | THIO/ESTER PEPTIDES | UNIVERSITY OF MIAMI (US) | 1988-05-17 | — | — | US | disclosed |
| US-4690936-A | AMINO ACIDS, THIOESTER LINKAGE; ANGIOTENSIN INHIBITORS | UNIVERSITY OF MIAMI (US) | 1987-09-01 | — | — | US | disclosed |