Dibromotyrosine

Dibromotyrosine

SCHEMBL145219

N[C@@H](Cc1cc(Br)c(O)c(Br)c1)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 4/20 0.58
THRA P10827 2/20 0.58
PPARG P37231 2/20 0.58
SLC7A5 Q01650 5/20 0.55
HSD17B10 Q99714 5/20 0.54
USP2 O75604 4/20 0.54
ADORA3 P0DMS8 3/20 0.54
ALOX15 P16050 3/20 0.54
PTGS1 P23219 2/20 0.54
PTGS2 P35354 2/20 0.54
KDM4E B2RXH2 2/20 0.54
RECQL P46063 2/20 0.54
HIF1A Q16665 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
EGFR P00533 1/20 0.54
LCK P06239 1/20 0.54
FYN P06241 1/20 0.54
HTR2A P28223 1/20 0.54
SIRT5 Q9NXA8 1/20 0.54
PKM P14618 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dibromotyrosine SCHEMBL838919 1.00 THRB (0.58) THRBTHRAPPARGSLC7A5HSD17B10
Dibromotyrosine SCHEMBL145218 1.00 THRB (0.58) THRBTHRAPPARGSLC7A5HSD17B10
Dibromotyrosine SCHEMBL29399010 0.98 THRB (0.57) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL10667474 0.89 THRB (0.52) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL10667480 0.89 THRB (0.52) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL7301146 0.85 SLC7A5 (0.53) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL838942 0.84 SLC7A5 (0.52) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL837750 0.84 SLC7A5 (0.52) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL5083101 0.81 SLC7A5 (0.57) THRBTHRAPPARGSLC7A5HSD17B10
SCHEMBL7448572 0.81 SLC7A5 (0.57) THRBTHRAPPARGSLC7A5HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1064 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12428447-B2 Peptide-based non-proteinaceous cargo delivery FELDAN BIO INC. (CA) 2025-09-30 US claimed
WO-2025094171-A1 SUPERHYDROPHOBIC COATING YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2025-05-08 WO claimed
US-12077611-B2 Cyclic peptides multimers targeting α4β7 integrin ZEALAND PHARMA A/S (DK) 2024-09-03 US claimed
EP-4401555-A1 ANTIMICROBIAL PEPTIDES YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2024-07-24 EP claimed
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY FELDAN BIO INC. (CA) 2024-06-20 US claimed
CN-117750978-A Synthetic peptide shuttle bioconjugates for intracellular cargo delivery 费尔丹生物公司 2024-03-22 CN claimed
EP-4313159-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY Feldan Bio Inc. (CA) 2024-02-07 EP claimed
US-20240025949-A1 Beta-Arrestin Effectors and Compositions and Methods of Use Thereof TREVENA, INC. 2024-01-25 US claimed
US-20230406884-A1 CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN ZEALAND PHARMA A/S (DK) 2023-12-21 US claimed
US-20230399661-A1 SHUTTLE AGENT PEPTIDES OF MINIMAL LENGTH AND VARIANTS THEREOF ADAPTED FOR TRANSDUCTION OF CAS9-RNP AND OTHER NUCLEOPROTEIN CARGOS FELDAN BIO INC. (CA) 2023-12-14 US claimed
US-5475138-A Method preparing amino acid-derived diaminopropanols PHARM-ECO LABORATORIES INCORPORATED (US) 1995-12-12 US claimed
US-4960881-A REACTING AMINO ACID WITH ALPHA-CHLORINATED CARBONATE IN SOLVENT IN PRESENCE OF ACID SCAVENGER SOCIETE NATIONALE DES POUDRES ET EXPLOSIFS (FR) 1990-10-02 US claimed
US-4801742-A N-formylation of amino carboxylates with alkyl formates W. R. GRACE & CO.-CONN. (US) 1989-01-31 US claimed
US-4614770-A HYDROCYANATION OF CARBONYL, THIOCARBONYL OR IMINO GROUPS; POLYMERS BEARING PYRIDINE-NUCLEUS RING SUBSTITUTED BY CARBOXAMIDE GROUPS ALLIED CORPORATION (US) 1986-09-30 US claimed
US-4614769-A NADH2 mimics as chiral pseudohydrogenases ALLIED CORPORATION (US) 1986-09-30 US claimed
US-4524223-A CHROMATOGRAPHIC SEPARATION OF DIASTEREOMERIC ESTERS UOP INC. (US) 1985-06-18 US claimed
US-4418225-A ESTERIFICATION WITH AMINO ACIDS UOP INC. (US) 1983-11-29 US claimed
EP-0046270-A1 Novel derivatives of bio-affecting phenolic compounds and pharmaceutical composition containing them INTERx RESEARCH CORPORATION (US) 1982-02-24 EP claimed
US-4242256-A Synthesis of peptide analogues SHARPE ROBERT (GB) 1980-12-30 US claimed
US-3930948-A ENZYMATIC METHOD FOR PRODUCING AROMATIC ETHYLAMINES AJINOMOTO CO., INC. (JA) 1976-01-06 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240197896-A1 SYNTHETIC PEPTIDE SHUTTLE AGENT BIOCONJUGATES FOR INTRACELLULAR CARGO DELIVERY SCAMP2, SLC7A1, NUMA1 THRB 3121/4885THRA 2669/4885PPARG 3587/4885
US-12077611-B2 Cyclic peptides multimers targeting α4β7 integrin ITGB7, ITGB4, ITGA4 THRB 416/4885THRA 762/4885PPARG 4066/4885
US-20230406884-A1 CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN ITGB7, ITGB4, ITGA4 THRB 239/4885THRA 520/4885PPARG 4287/4885
US-20240025949-A1 Beta-Arrestin Effectors and Compositions and Methods of Use Thereof ARRB1, FGB, SARS1 THRB 459/4885THRA 1938/4885PPARG 3342/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.