Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.88 |
| ▸ | TFEB | P19484 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.59 |
| ▸ | BACE1 | P56817 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10667601 | 1.00 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL5598851 | 0.94 | NFE2L2 (1.00) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL5598849 | 0.94 | NFE2L2 (1.00) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL10756384 | 0.88 | NFE2L2 (0.78) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL7414394 | 0.88 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL7414400 | 0.88 | NFE2L2 (0.88) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL10666681 | 0.87 | NFE2L2 (0.89) | NFE2L2KDM4EMAPTNPC1LMNA | |
| SCHEMBL10666700 | 0.87 | NFE2L2 (0.89) | NFE2L2KDM4EMAPTNPC1LMNA | |
| SCHEMBL11549762 | 0.86 | NFE2L2 (0.74) | NFE2L2TFEBKDM4EMAPTNPC1 | |
| SCHEMBL11545959 | 0.85 | NFE2L2 (0.72) | NFE2L2TFEBKDM4EMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4727066-A | CARDIOVASCULAR DISORDERS | CERMOL S.A. (CH) | 1988-02-23 | — | — | US | disclosed |
| US-4656181-A | CARDIOTONIC AGENTS | CERMOL S.A. (CH) | 1987-04-07 | — | — | US | disclosed |
| US-4532248-A | Administering 1,4-dihydropyridine derivative exhibiting positive inotropic activity | BAYER AKTIENGESELLSCHAFT (DE) | 1985-07-30 | — | — | US | disclosed |
| US-3932646-A | CORONARY VASODILATORS, HYPOTENSIVE AGENTS | FARBENFABRIKEN BAYER AG (DT) | 1976-01-13 | — | — | US | disclosed |